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Blood cells. Credit score: © phonlamaiphoto / Fotolia Scientists at Lund College in Sweden have developed a brand new understanding of how the primary blood cells kind throughout  human improvement as they transition from endothelial cells to kind blood cells of various varieties. Utilizing a laboratory mannequin of human stem cell improvement and by trying on the expression of blood cell and endothelial cell genes in every particular person cell, they discovered a development from an endothelial state, to a combined endothelial/blood state, to a blood-only state. That is the primary examine displaying the molecular processes of this transition within the human developmental context. "Understanding how the primary human blood cells develop will present lacking clues for us to generate blood stem cells within the laboratory to be used within the therapy of blood issues and malignancies," says Niels-Bjarne Woods, in command of the examine. The blood working...

To address this challenge, in 2010, the US National Heart, Lung, and Blood Institute's (NHLBI) Next Generation Genetic Association Studies Consortium sponsored a series of studies that began the hard work of analyzing induced pluripotent stem (iPS) cells gathered from large groups of patients to learn more about how individual mutations contribute to polygenetic diseases. Now, a group of 11 reports resulting from the collaborative effort appear in  Cell Stem Cell ,  Stem Cell Reports , and  EBioMedicine . The papers are presented on an interactive web portal,  http://www.cell.com/consortium/NextGen . "When this started, the stem cell field had begun to get to the point where you could contemplate making iPS cells at scale for perhaps hundreds or thousands of individuals," says Chad Cowan of the Harvard Stem Cell Institute, Massachusetts General Hospital, and the Broad Institute. "The time was right and the NHLBI had the vision to know that the next step in genome...

Adult men can have their sperm frozen before undergoing radiation or chemotherapy , both of which can render sperm infertile. But boys who haven't been through puberty can only have sperm stem cells removed and frozen in anticipation of technology that could culture the cells and place them back in the testes, where they produce sperm after puberty. Jon Oatley, an associate professor in the WSU School of Molecular Biosciences and director of the Center for Reproductive Biology, said he and his colleagues are well on their way to developing such a technology. "I think it's going to become the standard by which everybody cultures their cells, including trying to develop conditions for human cells," said Oatley. He and his colleagues -- graduate student Aileen Helsel and lab manager Melissa Oatley -- report on the new technique in the journal  Stem Cell Reports . Stem cell can produce 5,000 sperm Fewer than 1 percent of the nation's cancer cases involve ch...

Human EPS cells (inexperienced) might be detected in each the embryonic half (left) and extra-embryonic components (placenta and yolk sac, proper) of a mouse embryo. Credit score: Salk Institute When scientists discuss laboratory stem cells being totipotent or pluripotent, they imply that the cells have the potential, like an embryo, to grow to be any kind of tissue within the physique. What totipotent stem cells can do this pluripotent ones cannot do, nonetheless, is grow to be tissues that help the embryo, just like the placenta. These are referred to as extra-embryonic tissues, and are very important in improvement and wholesome progress. Now, scientists on the Salk Institute, in collaboration with researchers from Peking College, in China, are reporting their discovery of a chemical cocktail that permits cultured mouse and human stem cells to just do that: generate each embryonic and extra-embryonic ...